Evaluation of Hyperthermia of Magnetic Nanoparticles by Dehydrating DNA

نویسندگان

  • Lina Yu
  • Jinming Liu
  • Kai Wu
  • Todd Klein
  • Yong Jiang
  • Jian-Ping Wang
چکیده

A method based on the thermodynamic equilibrium reached between the hybridization and denaturation of double-stranded DNA (ds-DNA) is opened up to evaluate the hyperthermia performance of magnetic nanoparticles (MNPs). Two kinds of MNPs with different sizes and magnetic performance are chosen, and their temperature increments at the surface area under an alternating magnetic field (AMF) are calculated and compared through the concentration variation of ds-DNA modified on the surface. The temperature difference between the surface area of MNPs and bulk solution is also investigated, which can reach as high as 57.8°C when AMF applied for 300 s. This method provides a direct path way of comparison hyperthermia ability of MNPs, and serves as a good reference to choose MNPs and decides the therapy parameters based on the unique drug response of individual patient.

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عنوان ژورنال:

دوره 4  شماره 

صفحات  -

تاریخ انتشار 2014